Lack of correlation between morphological and biochemical parameters in mammary adenocarcinomas of rats induced with 7, 12-dimethylbenz(a)anthracene.

نویسندگان

  • R Hilf
  • H Goldenberg
  • M Gruenstein
  • D R Meranze
  • M B Shimkin
چکیده

Mammary tumors induced by 7,12-dimethylbenz(a)anthracene were divided into slowand fast-growing neo plasms on the basis of growth rate. Biochemical and histological evaluation was performed on each group and the data were compared. Of the 21 different parameters ex amined, significant differences were found in 3: isocitrate dehydrogenase and hexokinase activities and triglycéride content. None of the parameters demonstrated any cor relation with growth rate, although there were many co ordinated biochemical changes.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

In vivo assessment of anti-tumor activity of Methyl 2'-Methyl-1,3-dioxo-1,1',2',3,5',6',7',7a'-octahydrospiro[indene-2,3'-pyrrolizidine]-2' carboxylate (6) on 7,12 dimethylbenz(a) anthracene-induced mammary tumors in rat

Objective- Breast cancer is one of the most serious problems in oncology. Alkaloids pyrrolizidine are widely found in nature and exhibited versatile biological activities. The aim of the present study was to assess anti-tumor activity of methyl 1,3-dioxo-1,1',2',3,5',6',7',7a'-octahydrospiro[indene-2,3'-pyrrolizidine]-2'-carboxylate (6) on 7,12 dimethylbenz(a) anthracene (DMBA)-induced mammary ...

متن کامل

The effect of Ficus carica latex on 7, 12-dimethylbenz (a) anthracene-induced breast cancer in rats

Objective: In traditional medicine, Ficus carica (also known as fig) latex is recognized as a remedy with various therapeutic effects. Recently, in vitro studies have reported the anticancer effect of this latex on cancer cell lines. This study evaluated the effect of this latex on breast cancer growth, hematological parameters, and histopathology in rats. Materials and Methods: Twenty-four fem...

متن کامل

Hematologic status in DMBA-induced mammary gland carcinoma in sprague dawley rats

in this study,14 female sprague-dawley rats 55 days old were randomly divided into two control and experimental groups.2ml of 7,12-dimethylbenz{a} anthracene (DMBA) solution(20 mg of DMBA dissolved in 2 ml of corn oil) and 2 ml corn oil was eaten to each animal of test and control group respectively.tumor development was examined by milk line palpation once every week.during 3-5 months followin...

متن کامل

EFFECT OF IRON OVERLOAD ON 7, 12-DIMETHYLBENZ (A) ANTHRACENE-INDUCED SKIN TUMORIGENESIS

Iron overload is known to occur in the West European and American population due to the consumption of iron-rich diets. On the other hand, genetic disorders leading to iron overload are also known. Iron overload leads to increased peroxidation and disruptive disintegration of lipid-rich membranes, and predisposes humans for an enhanced risk of cancer induction. In experimental animals iron ...

متن کامل

Influence of Prolactin and Growth Hormone on Rat Mammary Tumors Induced by N-Nitrosomethylurea1

The effects of hypophysectomy and prolactin-suppressing drugs on the growth of mammary tumors induced in SpragueDawley rats by N-nitrosomethylurea and dimethylbenz(a)anthracene were compared. The influence of ovine prolactin and growth hormone administration on W-nitrosomethylurea-induced tumors was also studied in hypophysectomized animals. After hypophysectomy, all 13 tumors induced in 13 rat...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Cancer research

دوره 30 5  شماره 

صفحات  -

تاریخ انتشار 1970